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Growing interest in overgrowth
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Introduction |
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Congenital malformations or complex malformation syndromes are frequently associated with growth failure and have been the subject of much research and discussion in the paediatric literature. The less common overgrowth syndromes (OGSs) have until recently received little attention. The disordered growth in OGSs is, however, a primary anomaly and, unlike growth failure, is not explained away as a secondary phenomenon as is the case with many other complex syndromes. OGSs may therefore provide a fascinating window into the mechanisms of growth and the consequences of the failure of this regulation.
Ancient literature has many references to giants such as Goliath,
Polyphemus, Gargantua, or the Patagonian giants. Whether real or
fictional, these reports show that such patterns have been present
throughout history and serve to highlight two of the central
issues
what is a "true overgrowth syndrome and how many overgrowth
syndromes exist?"
Previously, overgrowth patterns were often categorised as primary
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