Annotation
 | Molecular basis of virulence |
| Commentary |
Molecular basis of virulence
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Advances in molecular biology, cell biology, and several other
areas of science have changed the way we understand the mechanisms in
which microbial pathogens interact with their hosts. This trend is set
to continue with the advent of microbial genome sequencing, in vivo
gene expression analysis, and other related techniques. The
availability of these techniques and advances in other areas such as
protein expression and crystallography has allowed the understanding of
host pathogen interaction at the molecular and even atomic level.
However, despite these powerful approaches the basic concept advanced
many years ago by Smith that pathogenicity or virulence is a
multifactorial property that consists of five basic steps is still
valid today.1 The molecular basis of virulence can still
be considered under these five headings: (1) attachment to the host
(via mucous membranes); (2) entry into the host (usually); (3)
multiplication within the host; (4) Interference with host defence
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