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Targeted radiotherapy for neuroblastoma
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Background |
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Biologically targeted radiotherapy is an established treatment for
thyrotoxicosis and thyroid cancer.1 The principle is to
take advantage of the ability of the thyroid and, to a lesser degree,
differentiated thyroid carcinoma to concentrate and retain iodide. In
this situation the radionuclide (131I) in ionic form is a
natural substrate for targeting thyroid tissue, thus acting both as the
vector, or `missile', and the `warhead'. The success of this form
of radiotherapy in metastatic papillary and follicular thyroid
carcinoma2 is due to the specificity of targeting and the
resulting concentration and retention of 131I in cells of
thyroid origin, after the ablation of residual normal thyroid tissue,
being sufficient to result in tumour eradication. Unfortunately the
thyroid is unique and targeted radioiodine treatment for other tumours
requires specific vectors to carry the `warhead'.With the development
of monoclonal antibodies in 19753 it was hoped that
Erlich's concept of an immunological
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Oyen, W. J. G., Bodei, L., Giammarile, F., Maecke, H. R., Tennvall, J., Luster, M., Brans, B.
(2007). Targeted therapy in nuclear medicine current status and future prospects. Ann Oncol
18: 1782-1792
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