Letters to the editor
Intestinal neuronal dysplasia associated with cystic fibrosis
| The first 150 words of the full text of this article appear below. |
EDITOR,
The association between cystic fibrosis and
intestinal neuronal dysplasia (IND) has been rarely
described.1 We report a case of full thickness, biopsy
proved, IND type B of the ileum and colon associated with cystic
fibrosis. The boy was born at full term to non-consanguineous parents.
Because of obstructive symptoms, several resections were performed: 20 cm of distal ileum after birth; distal ileum and part of ascending
colon at the age of 18 days; ileum, part of jejunum, and colon at the
age of 2 months. A series of radiographs of the upper gastrointestinal tract series showed a normal duodenum at 16 months and no dilatations of the remaining intestinal tract. Contrast appeared in the rectum after 90 minutes. By histology, the proximal ileal tract had 6.25 neurons/mm of myenteric plexus, according to Smith's method (normal values: 2-4),2 the ascending colon 16.0 neurons/mm, and
the transverse colon 8 neurons/rnm. Acetylcholinesterase staining showed an increase
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