Annotation
Vitamin A prophylaxis
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Introduction |
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It has been little more than a decade since the initial
observation of the dose dependent relation between the severity of vitamin A deficiency and childhood mortality,1 quickly
followed by the publication of a controlled trial in which children of preschool age, randomised to receive large doses of vitamin A every six
months, died at only two thirds (or less) the rate of control
subjects.2 3 In the short interval since this trial, an
initially sceptical scientific community has declared control of
vitamin A deficiency a major international goal4-6 and
potentially one of the most cost effective of all health
interventions.7
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The story did not begin in the 1980s. A host of animal studies and anecdotal clinical reports during the first third of the century, soon after vitamin A was discovered, suggested a close, potentially causal relation between vitamin A status and morbidity and mortality from infection. These are detailed elsewhere.8
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Vitamin A prophylaxis and mortality |
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This article has been cited by other articles:
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Rosales, F. J.
(2002). Vitamin A Supplementation of Vitamin A Deficient Measles Patients Lowers the Risk of Measles-Related Pneumonia in Zambian Children. J. Nutr.
132: 3700-3703
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