SHORT REPORT

Type 2 diabetes in obese white children

A J Drake¹, A Smith², P R Betts², E C Crowne¹, J P H Shield¹

¹ The Royal Hospital for Children, The Paul O'Gorman Building, Upper Maudlin Street, Bristol BS2 8BJ, UK
² Southampton University Hospitals Trust, Tremona Road, Southampton SO16 6YD, UK

Correspondence to:
Correspondence to:
Dr J P H Shield, Consultant Senior Lecturer, The Royal Hospital for Children, The Paul O'Gorman Building, Upper Maudlin Street, Bristol BS2 8BJ, UK;
j.p.h.shield{at}bristol.ac.uk

We report four white adolescents aged 13 to 15 years (three females, one male) from the south and west region of England who presented with type 2 diabetes mellitus associated with significant obesity (body mass index more than +3SDS) in the past two years. Although these are the first reported obese, white cases from the UK to present with diabetes, we believe this clinical scenario will become more prevalent given the epidemic of childhood obesity in this country.

Keywords: type 2 diabetes; obesity; screening

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Nugent, D. A., Smith, D. M., Jones, H. B. (2008). A Review of Islet of Langerhans Degeneration in Rodent Models of Type 2 Diabetes. Toxicol Pathol 36: 529-551 [Abstract] [Full Text]  
• Khunti, K., Stone, M. A., Bankart, J., Sinfield, P., Pancholi, A., Walker, S., Talbot, D., Farooqi, A., Davies, M. J. (2008). Primary prevention of type-2 diabetes and heart disease: action research in secondary schools serving an ethnically diverse UK population. J Public Health (Oxf) 30: 30-37 [Abstract] [Full Text]  
• Sabin, M. A., De Hora, M., Holly, J. M.P., Hunt, L. P., Ford, A. L., Williams, S. R., Baker, J. S., Retallick, C. J., Crowne, E. C., Shield, J. P.H. (2007). Fasting Nonesterified Fatty Acid Profiles in Childhood and Their Relationship With Adiposity, Insulin Sensitivity, and Lipid Levels. Pediatrics 120: e1426-e1433 [Abstract] [Full Text]  
• Riddoch, C. J, Mattocks, C., Deere, K., Saunders, J., Kirkby, J., Tilling, K., Leary, S. D, Blair, S. N, Ness, A. R (2007). Objective measurement of levels and patterns of physical activity. Arch. Dis. Child. 92: 963-969 [Abstract] [Full Text]  
• Khunti, K., Stone, M. A, Bankart, J., Sinfield, P. K, Talbot, D., Farooqi, A., Davies, M. J (2007). Physical activity and sedentary behaviours of South Asian and white European children in inner city secondary schools in the UK. Fam Pract 24: 237-244 [Abstract] [Full Text]  
• Stone, M. A, Bankart, J., Sinfield, P., Talbot, D., Farooqi, A., Davies, M. J, Khunti, K. (2007). Dietary habits of young people attending secondary schools serving a multiethnic, inner-city community in the UK. Postgrad. Med. J. 83: 115-119 [Abstract] [Full Text]  
• Alton, D, Adab, P, Roberts, L, Barrett, T (2007). Relationship between walking levels and perceptions of the local neighbourhood environment. Arch. Dis. Child. 92: 29-33 [Abstract] [Full Text]  
• Flegal, K. M., Tabak, C. J., Ogden, C. L. (2006). Overweight in children: definitions and interpretation. Health Educ Res 21: 755-760 [Abstract] [Full Text]  
• Gibson, L. J, Peto, J., Warren, J. M, Silva, I. d. S. (2006). Lack of evidence on diets for obesity for children: a systematic review. Int J Epidemiol 35: 1544-1552 [Abstract] [Full Text]  
• Druet, C., Tubiana-Rufi, N., Chevenne, D., Rigal, O., Polak, M., Levy-Marchal, C. (2006). Characterization of Insulin Secretion and Resistance in Type 2 Diabetes of Adolescents. J. Clin. Endocrinol. Metab. 91: 401-404 [Abstract] [Full Text]  
• Sabin, M A, Ford, A L, Holly, J M P, Hunt, L P, Crowne, E C, Shield, J P H (2006). Characterisation of morbidity in a UK, hospital based, obesity clinic. Arch. Dis. Child. 91: 126-130 [Abstract] [Full Text]  
• Ehtisham, S., Crabtree, N., Clark, P., Shaw, N., Barrett, T. (2005). Ethnic Differences in Insulin Resistance and Body Composition in United Kingdom Adolescents. J. Clin. Endocrinol. Metab. 90: 3963-3969 [Abstract] [Full Text]  
• Scaglioni, S., Sala, M., Stival, G., Giroli, M., Raimondil, C., Salvioni, M., Radaelli, G., Agostoni, C., Riva, E., Giovannini, M. (2005). Dietary Glycemic Load and Macronutrient Intake in Healthy Italian Children. Asia Pac J Public Health 17: 88-92 [Abstract]  
• Grohmann, M., Sabin, M., Holly, J., Shield, J., Crowne, E., Stewart, C. (2005). Characterization of differentiated subcutaneous and visceral adipose tissue from children: the influences of TNF-{alpha} and IGF-I. J. Lipid Res. 46: 93-103 [Abstract] [Full Text]  
• Viner, R M, Segal, T Y, Lichtarowicz-Krynska, E, Hindmarsh, P (2005). Prevalence of the insulin resistance syndrome in obesity. Arch. Dis. Child. 90: 10-14 [Abstract] [Full Text]  
• Porter, J R, Barrett, T G (2004). Acquired non-type 1 diabetes in childhood: subtypes, diagnosis, and management. Arch. Dis. Child. 89: 1138-1144 [Abstract] [Full Text]  
• Wilkin, T. J, Voss, L. D (2004). Metabolic syndrome: maladaptation to a modern world. JRSM 97: 511-520 [Full Text]  
• Alberti, G., Zimmet, P., Shaw, J., Bloomgarden, Z., Kaufman, F., Silink, M. (2004). Type 2 Diabetes in the Young: The Evolving Epidemic: The International Diabetes Federation Consensus Workshop. Diabetes Care 27: 1798-1811 [Full Text]  
• Weill, J, Vanderbecken, S, Froguel, P (2004). Understanding the rising incidence of type 2 diabetes in adolescence. Arch. Dis. Child. 89: 502-504 [Full Text]  
• Ehtisham, S, Hattersley, A T, Dunger, D B, Barrett, T G (2004). First UK survey of paediatric type 2 diabetes and MODY. Arch. Dis. Child. 89: 526-529 [Abstract] [Full Text]  
• Bloomgarden, Z. T. (2004). Type 2 Diabetes in the Young: The evolving epidemic. Diabetes Care 27: 998-1010 [Full Text]  
• Fox, K. R (2004). Childhood obesity and the role of physical activity. The Journal of the Royal Society for the Promotion of Health 124: 34-39 [Abstract]  
• Murphy, M. J., Metcalf, B. S., Voss, L. D., Jeffery, A. N., Kirkby, J., Mallam, K. M., Wilkin, T. J. (2004). Girls at Five Are Intrinsically More Insulin Resistant Than Boys: The Programming Hypotheses Revisited--The EarlyBird Study (EarlyBird 6). Pediatrics 113: 82-86 [Abstract] [Full Text]  
• St-Onge, M.-P., Keller, K. L, Heymsfield, S. B (2003). Changes in childhood food consumption patterns: a cause for concern in light of increasing body weights. Am. J. Clin. Nutr. 78: 1068-1073 [Abstract] [Full Text]  
• Khunti, K., Davies, M. (2003). Primary prevention of type 2 diabetes in people of South Asian origin: potential roles of schools. British Journal of Diabetes & Vascular Disease 3: 432-433 [Abstract]  
• Armstrong, J, Dorosty, A R, Reilly, J J, Child Health Information Team, , Emmett, P M (2003). Coexistence of social inequalities in undernutrition and obesity in preschool children: population based cross sectional study. Arch. Dis. Child. 88: 671-675 [Abstract] [Full Text]  
• Ramachandran, A., Snehalatha, C., Satyavani, K., Sivasankari, S., Vijay, V. (2003). Type 2 Diabetes in Asian-Indian Urban Children. Diabetes Care 26: 1022-1025 [Abstract] [Full Text]  
• Wilson, P, O'Meara, S, Summerbell, C, Kelly, S (2003). The prevention and treatment of childhood obesity. Qual Saf Health Care 12: 65-74 [Abstract] [Full Text]  
• Wormald, H., Sleap, M., Brunton, J., Hayes, L., Warburton, P., Waring, M., White, M. (2003). Methodological issues in piloting a physical activity diary with young people. Health Education Journal 62: 220-233 [Abstract]  
• Colhoun, H. M. (2002). The big picture on obesity and insulin resistance. J Am Coll Cardiol 40: 944-945 [Full Text]  
• Pinkney, J. (2002). Prevention and cure of type 2 diabetes. BMJ 325: 232-233 [Full Text]