Arch Dis Child. Published Online First: 12 May 2009. doi:10.1136/adc.2008.156406
Original articles |
Treatment of Acne with Oral Isotretinoin in Patients with Cystic Fibrosis
1 Royal Children's Hospital, Australia
* To whom correspondence should be addressed. E-mail: rod.phillips{at}rch.org.au.
Accepted 29 April 2009
Abstract
Background: Theoretical concerns about liver disease and vitamin A deficiency have limited the use of oral isotretinoin for troublesome acne in adolescents with cystic fibrosis.
Methods: We administered oral isotretinoin to 9 patients with cystic fibrosis who had troublesome acne unresponsive to antibiotics. All patients were followed for 1-4 years after cessation of treatment.
Results: Isotretinoin treatment cleared active acne lesions in all patients. It was well tolerated and no patient had significant side effects. All nine patients were pleased or delighted with the improvement in their skin.
Conclusions: Adolescents with cystic fibrosis and acne can be treated with oral isotretinoin. Oral isotretinoin should be considered for adolescents with cystic fibrosis who have acne associated with scarring, acne not clearing with topical and antibiotic treatment, acne associated with depression, or severe cystic acne.
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