Archives of Disease in Childhood 2008;93:590-593
Original articles
Weight gain with pizotifen therapy
Department of Paediatrics, West Suffolk Hospital, Bury St Edmunds, UK
Dr G L Briars, Department of Paediatrics, West Suffolk Hospital, Hardwick Lane, Bury St Edmunds IP33 2QZ, UK; g.briars{at}doctors.org.uk
Objective: To describe the characteristics of weight gain occurring in children treated for migranous conditions with pizotifen
Design: Retrospective case note review
Setting: West Suffolk Hospital between 1999 and 2003
Patients: 405 clinic attendances of 121 children receiving pizotifen treatment
Main outcome measures: Rates of change in weight for age z score between successive outpatient appointments were used to detect excessive weight gain.
Results: The mean rate of weight z score increase for 105 patients receiving a constant dosage in 181 intervals between appointments was 0.79 standard deviations per year compared with 0.11 standard deviations per year for height z score increases. The rate of weight z score increase was not correlated with pizotifen dose per kg (r = –0.08), per m2 (r = –0.05) or initial body mass index (r = –0.04). Mean rates of z score increase were similar in patients with a satisfactory and unsatisfactory therapeutic responses.
Conclusions: Excess weight gain in pizotifen therapy is not predicted by drug dosage or therapeutic response within the range of doses used in clinical practice.
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