Arch Dis Child. Published Online First: 13 March 2008. doi:10.1136/adc.2007.128579
Original articles |
Vitamin D Supplementation in Early Childhood and Risk of Type 1 Diabetes: a Systematic Review and Meta-analysis
1 Central Manchester and Manchester Children's University Hospitals, United Kingdom
2 Booth Hall Children's, United Kingdom
* To whom correspondence should be addressed. E-mail: czipitis{at}hotmail.com.
Accepted 17 January 2008
Abstract
Objectives: To assess whether vitamin D supplementation in infancy reduces risk of type 1 diabetes in later life.
Design: Systematic review and meta-analysis. Data sources: Medline, Embase, Cinahl, Cochrane Central Register of Controlled Trials and reference lists of retrieved articles.
Main outcome measure: Development of type 1 diabetes.
Inclusion criteria: Controlled trials and observational studies which had assessed the effect of vitamin D supplementation on risk of developing type 1 diabetes.
Results: Five observational studies met the inclusion criteria; no randomised controlled trials were found. 4 of the 5 included studies were case control studies and the fifth study was a cohort study. Meta-analysis of data from the case control studies showed that the risk of type 1 diabetes was significantly reduced in infants who were supplemented with vitamin D compared to those who were not supplemented (pooled odds ratio 0.71, 95% CI 0.60 to 0.84). The result of the cohort study was in agreement with that of the meta-analysis. There was also some evidence of a dose-response effect, with those using higher amounts of vitamin D being at lower risk of developing type 1 diabetes. Finally, there was a suggestion that the timing of supplementation might also be important for the subsequent development of type 1 diabetes.
Conclusion: Vitamin D supplementation in early childhood may offer protection against the development of type 1 diabetes. The evidence for this is based on observational studies. Adequately powered, randomised controlled trials with long periods of follow-up are needed to establish causality and the best formulation, dose, duration and period of supplementation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Atoms
- Howard Bauchner
Arch. Dis. Child. 2008 93: i.[Extract] [Full Text] [PDF]
This article has been cited by other articles:
-
Mansbach, J. M., Ginde, A. A., Camargo, C. A. Jr
(2009). Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D?. Pediatrics
124: 1404-1410
[Abstract] [Full Text] -
Martin, R. J. L., McKnight, A. J., Patterson, C. C., Sadlier, D. M., Maxwell, A. P., The Warren 3/UK GoKinD Study Group,
(2009). A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy. Nephrol Dial Transplant
0: gfp515v1-gfp515
[Abstract] [Full Text] -
Chase, H. P., Lescheck, E., Rafkin-Mervis, L., Krause-Steinrauf, H., Chritton, S., Asare, S. M., Adams, S., Skyler, J. S., Clare-Salzler, M., , and the Type 1 Diabetes TrialNet NIP Study Group,
(2009). Nutritional Intervention to Prevent (NIP) Type 1 Diabetes A Pilot Trial. ICAN: Infant, Child, & Adolescent Nutrition
1: 98-107
[Abstract] -
Zipitis, C. S.
(2009). Is Vitamin D Protective Against Development of Type 1 Diabetes Mellitus?. ICAN: Infant, Child, & Adolescent Nutrition
1: 108-112
[Abstract] -
Wasserfall, C., Atkinson, M. A.
(2009). Taking a Daily Vitamin to Prevent Type 1 Diabetes?. Diabetes
58: 24-25
[Full Text] -
Lee, J. H., O'Keefe, J. H., Bell, D., Hensrud, D. D., Holick, M. F.
(2008). Vitamin D Deficiency: An Important, Common, and Easily Treatable Cardiovascular Risk Factor?. J Am Coll Cardiol
52: 1949-1956
[Abstract] [Full Text] -
Penckofer, S., Kouba, J., Wallis, D. E., Emanuele, M. A.
(2008). Vitamin D and Diabetes: Let the Sunshine In. The Diabetes Educator
34: 939-954
[Abstract] [Full Text]
- Full Text (Rapid PDF)
-
All Versions of this Article:
adc.2007.128579v1
93/6/512 most recent - Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
