Arch Dis Child. Published Online First: 19 May 2009. doi:10.1136/adc.2007.125872
Review |
Langerhans Cell Histiocytosis
1 Newcastle University, United Kingdom
2 Watford General Hospital, United Kingdom
* To whom correspondence should be addressed. E-mail: k.p.windebank{at}ncl.ac.uk.
Accepted 24 April 2009
Abstract
Langerhans Cell Histiocytosis is a rare disease. Depending on which organs are involved the disease may prove rapidly fatal, develop a chronic reactivating but therapy responsive pattern or resolve spontaneously. Understanding of the pathology of the disease is progressing rapidly and whilst clinical trials of standard chemotherapy agents continue, it is likely that novel targeted therapy will become feasible in the next decade. Permanent consequences of the disease are commoner than generally realised.
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