Archives of Disease in Childhood 2009;94:434-436
ORIGINAL ARTICLES
Work of breathing during SIMV with and without pressure support
Division of Asthma, Allergy and Lung Biology, School of Medicine, King’s College London, London, UK
Professor Anne Greenough, Newborn Unit, 4th Floor Golden Jubilee Wing, King’s College Hospital, Denmark Hill, London SE5 9RS, UK; anne.greenough{at}kcl.ac.uk
Objective: In a randomised trial, pressure support with synchronised intermittent mandatory ventilation (SIMV) compared to SIMV alone was associated with a significant reduction in supplementary oxygen duration. The hypothesis that the addition of pressure support to SIMV compared to SIMV alone would reduce the work of breathing was examined.
Design: Prospective study.
Setting: Perinatal service.
Patients: 20 infants, with a mean gestational age of 31 weeks, being weaned from mechanical ventilation were studied.
Interventions: 1 h periods of SIMV and SIMV with pressure support at 50% of the difference between the peak inflating pressure and positive end expiratory pressures.
Main outcome measures: The work of breathing was assessed by measurement of the transdiaphragmatic pressure time product (PTPdi).
Results: The mean PTPdi on SIMV plus pressure support was 112 cm H2O.s/min, approximately 20% lower than that on SIMV alone (141 cm H2O.s/min) (p<0.001).
Conclusion: The addition of pressure support to SIMV reduces the work of breathing in infants being weaned from the ventilator.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
adc.2008.152926v1
94/6/434 most recent - Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
