Archives of Disease in Childhood 2008;93:218-220
Original articles
No temporal association between influenza outbreaks and invasive pneumococcal infections
1 Institute for Social Pediatrics and Adolescent Medicine, Ludwig-Maximilians University Munich, Munich, Germany
2 Division of Health and Social Care Research, King’s College London, London, UK
3 Pediatric Infectious Diseases, University Children’s Hospital Kiel, Kiel, Germany
4 Department of Statistics, Ludwig-Maximilians University Munich, Munich, Germany
5 Division of Pediatric Infectious Diseases, University Children’s Hospital Basel, Basel, Switzerland
Professor Ulrich Heininger, University Children’s Hospital Basel, PO Box 4005, Basel, Switzerland; Ulrich.Heininger{at}unibas.ch
Objective: To assess whether the influenza peak in populations precedes the annual peak for invasive pneumococcal infections (IPI) in winter.
Design: Ecological study. Active surveillance data on influenza A and IPI in children up to 16 years of age collected from 1997 to 2003 were analysed.
Setting: Paediatric hospitals in Germany.
Patients: Children under 16 years of age.
Results: In all years under study, the influenza A season did not appear to affect the IPI season (p = 0.49). Specifically, the influenza peak never preceded the IPI peak.
Conclusion: On a population level there was no indication that the annual influenza epidemic triggered the winter increase in the IPI rate or the peak of the IPI distribution in children.
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