CASE REPORT
Postprandial hyperinsulinaemic hypoglycaemia and type 1 diabetes mellitus
London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, London, UK
Correspondence to:
Correspondence to:
Dr K Hussain
Developmental Endocrinology Research Group, Molecular Genetics Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK; K.Hussain{at}ich.ucl.ac.uk
A patient with severe postprandial hyperinsulinaemic hypoglycaemia (PPHH) for 4 years developed type 1 diabetes mellitus. She had no insulin or insulin receptor antibodies but was positive for islet cell and glutamic acid decarboxylase (GAD) antibodies. PPHH prior to the onset of type 1 diabetes mellitus has not been previously described and may be a prodrome of type 1 diabetes mellitus.
Abbreviations: DM, diabetes mellitus; GAD, glutamic acid decarboxylase; IAS, insulin autoimmune syndrome; OGTT, oral glucose tolerance test; PPHH, postprandial hyperinsulinaemic hypoglycaemia
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Arch. Dis. Child. 2007 92: e8.
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