ORIGINAL ARTICLE

Improved outcome of referrals for intestinal transplantation in the UK

Girish L Gupte¹, Susan V Beath¹, Sue Protheroe², M Stephen Murphy², Paul Davies³, Khalid Sharif¹, Patrick J McKiernan¹, Jean de Ville de Goyet⁴, Ian W Booth⁵, Deirdre A Kelly¹

¹ Liver Unit, Birmingham Children’s Hospital, Birmingham, UK
² Department of Paediatric Gastroenterology, Birmingham Children’s Hospital, Birmingham, UK
³ Statistical Advisory Service, Birmingham Children’s Hospital, Birmingham, UK
⁴ Liver Unit, Birmingham Children’s Hospital, Birmingham, UK (1998–2003)
⁵ Institute of Child Health, Birmingham, UK

Correspondence to:
Dr G L Gupte
Consultant Paediatric Hepatologist, Birmingham Children’s Hospital NHS Trust, Steelhouse Lane, Birmingham B4 6NH, UK; girish.gupte{at}bch.nhs.uk

Aim: To describe the outcome of children with intestinal failure referred to Birmingham Children’s Hospital (BCH) for consideration of intestinal transplantation (ITx), to determine factors for an adverse outcome and to analyse the impact of post-1998 strategies on survival.

Subjects and methods: A retrospective analysis was performed of children referred for ITx assessment from January 1989 to December 2003. Children were assessed by a multidisciplinary team and categorised into: (a) stable on parenteral nutrition; (b) unsuitable for transplantation (Tx); and (c) recommended for Tx. To analyse the impact of the post-1998 strategies on survival, a comparison was made between the two eras (pre-1998 and post-1998).

Results: 152 children with chronic intestinal failure were identified (63M:89F, median age 10 months (range 1–170)). After assessment, 69 children were considered stable on parenteral nutrition (5-year survival 95%); 28 children were unsuitable for Tx (5-year survival 4%); and 55 children were recommended for Tx (5-year survival 35%, which includes 14 children who died waiting for size-matched organs). Twenty three ITx and nine isolated liver transplants (iLTx) were performed. In a multivariate analysis, the following factors in combination had an adverse effect on survival: the presence of a primary mucosal disorder (p = 0.007, OR ratio 3.16, 95% CI 1.37 to 7.31); absence of involvement of a nutritional care team at the referring hospital (p = 0.001, OR ratio 2.55, 95% CI 1.44 to 4.52); and a serum bilirubin>100 µmol/l (p = 0.001, OR ratio 3.70, 95% CI 1.84 to 7.47). Earlier referral (median serum bilirubin 78 µmol/l in the post-1998 era compared with 237 µmol/l in the pre-1998 era, p = 0.001) may be a contributory factor to improved survival. The strategies of combined en bloc reduced liver/small bowel transplantation and iLTx resulted in fewer deaths on the waiting list in the post-1998 era (2 deaths in post-1998 era v 12 deaths in pre-1998 era). The overall 3-year survival in the post-1998 era (69%) has improved compared with the pre-1998 era (31%; p<0.001)

Conclusion: The changing characteristics at the time of referral, including earlier referral and innovative surgical strategies have resulted in improved long-term survival of children referred for ITx.

Abbreviations: BCH, Birmingham Children’s Hospital; IFALD, intestinal failure associated liver disease; SBS, short bowel syndrome

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