REVIEW

New insights into pulmonary inflammation in cystic fibrosis

S Rao¹, J Grigg²

¹ Department of Respiratory Medicine and Cystic Fibrosis, Birmingham Children’s Hospital NHS Trust, Steelhouse Lane, Birmingham B4 6NH, UK
² Institute of Cell and Molecular Science, Barts and The London, Queen Mary’s School of Medicine and Dentistry, London, UK

Correspondence to:
Correspondence to:
Dr J Grigg
Institute of Cell and Molecular Science, Barts and The London, Queen Mary’s School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK; j.grigg{at}qmul.ac.uk

Persistent lower airway infection with inflammation is the major cause of morbidity and mortality in cystic fibrosis. This review examines the recent advances in the understanding of airway inflammation in cystic fibrosis, and focuses on the evidence that pulmonary inflammation is, under some circumstances, disassociated from infection, and the potential implications for therapeutic intervention.

Keywords: cystic fibrosis; infection; inflammation

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

A brief digest of the September issue
Arch. Dis. Child. 2006 91: e5. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Brennan, S., Sly, P. D., Gangell, C. L., Sturges, N., Winfield, K., Wikstrom, M., Gard, S., Upham, J. W., on behalf of AREST CF, (2009). Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis. Eur Respir J 34: 655-661 [Abstract] [Full Text]  
• Wright, A. K. A., Rao, S., Range, S., Eder, C., Hofer, T. P. J., Frankenberger, M., Kobzik, L., Brightling, C., Grigg, J., Ziegler-Heitbrock, L. (2009). Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors. J. Leukoc. Biol. 86: 479-489 [Abstract] [Full Text]  
• Rowe, S. M., Jackson, P. L., Liu, G., Hardison, M., Livraghi, A., Solomon, G. M., McQuaid, D. B., Noerager, B. D., Gaggar, A., Clancy, J. P., O'Neal, W., Sorscher, E. J., Abraham, E., Blalock, J. E. (2008). Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease. Am. J. Respir. Crit. Care Med. 178: 822-831 [Abstract] [Full Text]