REVIEW

Perinatal hepatitis C virus infection: diagnosis and management

S M Davison¹, G Mieli-Vergani², J Sira³, D A Kelly³

¹ Children’s Liver and GI Unit, St James’s University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK
² Paediatric Liver Service, Department of Child Health, King’s College Hospital, London, UK
³ Liver Unit, Birmingham Children’s Hospital NHS Trust, Birmingham, UK

Correspondence to:
Correspondence to:
Dr S Davison
Children’s Liver and GI Unit, Ward 11, Gledhow Wing, St James’s University Hospital, Beckett Street, Leeds LS9 7TF, UK; Suzanne.davison{at}leedsth.nhs.uk

Hepatitis C virus (HCV) infection in children is becoming an increasing challenge to health professionals. As our understanding of the disease evolves, so must our diagnostic and management strategies. In the 1990s, when HCV testing became available, children identified with HCV infection in the UK were mostly those who had required blood products, particularly those with haematological disorders. Acquiring knowledge of the natural history of HCV infection was confounded by the co-morbidity of iron overload, viral co-infection, and chemotherapy.

Keywords: hepatitis C virus; perinatal; chronic hepatitis

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