© 2004 BMJ Publishing Group & Royal College of Paediatrics and Child Health
SHORT REPORT
1 Antitrypsin and the prevalence and severity of asthma
1 University Children’s Hospital, Munich, Germany
2 University of Münster, Institute of Epidemiology and Social Medicine, Germany
3 Children’s Hospital, Technical University, Dresden, Germany
Correspondence to:
Correspondence to:
Dr E von Mutius
Dr von Haunersche Kinderklinik, Lindwurmstr. 4, D-80337 München, Germany; Erika.Von.Mutius{at}med.uni-muenchen.de
In a random sample of children (aged 9–11 years; n = 5629), who were studied according to the ISAAC phase II protocol, heterozygosity of the 
1 antitrypsin (1-AT) Pi genotypes MS or MZ, or low 1-AT plasma levels, were not associated with an increased risk of developing asthma. Asthmatics with low levels of 1-AT were particularly prone to develop airway hyperresponsiveness and reduced lung function.
Keywords: childhood asthma; 1-antitrypsin heterozygosity; epidemiology
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Arch. Dis. Child. 2004 89: 201.
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