© 2003 BMJ Publishing Group & Royal College of Paediatrics and Child Health
SHORT REPORT
Long term effects of long chain polyunsaturated fats in hyperphenylalaninemic children
1 Department of Pediatrics, San Paolo Hospital, University of Milan, Milan, Italy
2 Department of Neurology, San Paolo Hospital
3 Unit of Medical Statistics, San Paolo Hospital
Correspondence to:
Correspondence to:
Dr C Agostoni, Department of Pediatrics, San Paolo Hospital, 8 Via A. di Rudinì, I-20142 Milano, Italy; e-mail:
agostoc{at}tin.it
Blood fatty acid status and visual function of 20 treated hyperphenylalaninemic (HPA) children, randomly allocated into two groups to receive supplementation of either long chain polyunsaturated fatty acids (LCPUFA), including docosahexaenoic acid (DHA), or placebo for 12 months, have been investigated three years after the end of the treatment. Although in the LCPUFA group blood DHA levels and P100 wave latency improved at the end of supplementation, they had returned to baseline after three years.
Keywords: diet; docosahexaenoic acid; hyperphenylalaninemic; long chain polyunsaturated fatty acids
Abbreviations: CE, cholesterol esters; DHA, docosahexaenoic acid; Ery, erythrocyte total lipids; EryPE, phosphatidylethanolamine; HPA, hyperphenylalaninemic; LCPUFA, long chain polyunsaturated fatty acids; Phe, phenylalanine; PL, phospholipids; TG, triglycerides; TL, total lipids; VEP, visual evoked potential
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