© 2002 Archives of Disease in Childhood
ORIGINAL ARTICLE
No association between asthma or allergy and the CCR5
32 mutation
1 Budai Children's Hospital, Hungary
2 Semmelweis University Budapest, Hungary
3 Heim Pál Pediatric Hospital, Hungary
4 Section of Molecular Immunology, Hungarian Academy of Sciences
Correspondence to:
Correspondence to:
Dr C Szalai, Heim Pál Pediatric Hospital Budapest, Hungary, PO Box 66, H-1958;
szalai{at}heim.sote.hu
Aims: To investigate whether the presence of the CCR5
32 allele was associated with atopy or asthma.
Methods: A total of 118 children with asthma, 145 children with non-asthmatic, but allergic phenotype, and 303 children without allergic or asthmatic disorders were studied.
Results: There were no significant differences in the frequency of CCR532, or in the distributions of genotypes between the groups. The relative eosinophil blood count was slightly lower in patients with heterozygous genotype, than in patients with wild type genotype.
Conclusion: No association was found between the susceptibility of allergy or asthma and the functional deficient CCR532 allele.
Keywords: asthma; allergy; chemokine
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This article has been cited by other articles:
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Batra, J, Sharma, M, Chatterjee, R, Sharma, S, Mabalirajan, U, Ghosh, B
(2005). CCR5 {Delta}32 deletion and atopic asthma in India. Thorax
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