ORIGINAL ARTICLE

Efficacy of school urinary screening for membranoproliferative glomerulonephritis type 1

Y Kawasaki, J Suzuki, R Nozawa, H Suzuki

Department of Pediatrics, Fukushima Medical University School of Medicine, Japan

Correspondence to:
Correspondence to:
Dr Y Kawasaki, Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima City, Fukushima 960-1295, Japan;
tomo{at}fmu.ac.jp

Aims: In order to evaluate the efficacy of a school urinary screening programme, children with membranoproliferative glomerulonephritis (MPGN) type 1 were studied.

Methods: A total of 52 patients who had been diagnosed with MPGN type 1 from 1970 to 1997 were studied; 35 were identified after 1974 on screening (group S), and 17 were identified by presenting symptoms (group N), mostly before 1989.

Results: Mean blood pressure was 89 mm Hg in group S and 104 mm Hg in group N; urinary protein excretion was 0.9 g/day in group S and 3.0 g/day in group N. Histopathological evidence of chronic changes was found in six group S and 15 group N patients. No patients in group S had renal insufficiency, but five patients in group N required regular haemodialysis.

Conclusions: Results suggest that early identification by school urinary screening may enable early management and so improve prognosis of MPGN.

Keywords: membranoproliferative glomerulonephritis; urinary screening; school; prognosis

Abbreviations: BUN, blood urea nitrogen; EM, electron microscopy; IF, immunofluorescence; Ig, immunoglobulin; LM, light microscopy; MD, mesangial deposit; MPGN, membranoproliferative glomerulonephritis; SEND, subendothelial deposit; SEPT, subepithelial deposit; SUS, school urinary screening

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Urinary screening and improved prognopsis of membranoproliferative glomerulonephritis

Hassib Narchi

ADC Online, 28 Jan 2002 [Full text]