Article
Sex hormone binding globulin concentration as a prepubertal
marker for hyperinsulinaemia in obesity
P J Gallowaya, M D C Donaldsonb, A M Wallacec
a Department of
Biochemistry, Royal Hospital for Sick Children, Yorkhill, Glasgow
G3 0SF, UK, b Department
of Child Health, University of Glasgow, Royal Hospital for Sick
Children, Yorkhill, c Department of Biochemistry, Macewen Building,
Glasgow Royal Infirmary, UK
Correspondence to: Dr Galloway petergalloway{at}lineone.net
Accepted 7 August 2001
BACKGROUND
Overweight children
become obese adults who are prone to develop the "metabolic
syndrome" and premature coronary arterial disease (CAD).
AIMSTo assess whether sex hormone
binding globulin (SHBG) is a potential marker for
hyperinsulinaemia/insulin resistance in prepubertal obese children.
METHODSTwenty five obese children
(body mass index (BMI) >2SD) who warranted investigation on clinical
grounds were enrolled. Their insulin response to an oral glucose
tolerance test was assessed.
RESULTSFourteen children were
hyperinsulinaemic. Despite being matched for age and BMI, SHBG
concentrations were below the sex related reference range in the
hyperinsulinaemic group.
CONCLUSIONOur results indicate
that a subnormal SHBG concentration in a prepubertal child is strongly
predictive of hyperinsulinaemia. By measuring the circulating SHBG
concentration, it might be possible to identify those at most risk of
premature CAD, targeting them for lifestyle changes.
Keywords: SHBG; insulin; prepubertal; obesity
© 2001 by Archives of Disease in Childhood
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