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Archives of Disease in Childhood 2001;84:432-433; doi:10.1136/adc.84.5.432
Copyright © 2001 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
Arch Dis Child 2001;84:432-433 ( May )

General and acute paediatrics

Short report

Bronchoconstriction following nebulised colistin in cystic fibrosis S Cunninghama, A Prasada, L Collyerb, S Carrb, I Balfour Lynnc, C Wallisa

a Portex Anaesthesia, Intensive Care and Respiratory Medicine, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK, b Barts & The London NHS Trust, Whitechapel, London E1 1BB, UK, c Royal Brompton & Harefield NHS Trust, Sydney Street, London SW3 6NP, UK

Correspondence to: Dr Cunningham steve.cunningham{at}talk21.com

Accepted 16 November 2000

Nebulised colistin is regularly used as antipseudomonal therapy in children with cystic fibrosis. We assessed bronchoconstriction in response to nebulised colistin in 58 children. Nebulised colistin significantly reduced FEV1, MEF25%, and SaO2 for 15 minutes. In 20 children the reduction was greater than 10% from baseline FEV1, and was still at that level in five at 30 minutes. Subjective assessment, baseline FEV1, and serum IgE were unable to identify susceptible children. It is recommended that children receiving colistin should be carefully assessed for bronchoconstriction.


Keywords: cystic fibrosis; colistin; bronchoconstriction

© 2001 by Archives of Disease in Childhood
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Nebulised Colistin in Cystic Fibrosis
Jayesh Bhatt
ADC Online, 30 May 2001 [Full text]

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