General and acute paediatrics
Short report
Niflumic acid and cutaneous reactions in children
F Menniti-Ippolitoa, L Saglioccab, R Da Casa, G Saggiomob, R Di Nardob, G Traversaa, and the Santobono Study Group for Adverse Drug Reactions in Children
a Department
of Epidemiology and Biostatistics, Istituto Superiore di Sanità,
Viale Regina Elena 299, 00161 Rome, Italy, b Santobono Hospital, Via Mario Fiore 6, 80129 Naples, Italy
Correspondence to: Dr Menniti-Ippolito fmenniti{at}iss.it
Accepted 19 January
2001
In a case control study of adverse drug reactions in children,
the odds ratio of developing a serious mucocutaneous event among users
of niflumic acid, adjusted for concomitant use of all other drugs, was
4.9 (95% CI 1.9 to 12.8). Given the availability of safer analgesics
and antipyretics, there is no indication, in our opinion, that requires
the prescription of substances which bear an increased risk.
Keywords: adverse drug reactions; niflumic acid; cutaneous reactions; pharmacoepidemiology
© 2001 by Archives of Disease in Childhood
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Arch. Dis. Child. 2001 85: 251.[Extract] [Full Text]
This article has been cited by other articles:
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Menniti-Ippolito, F., Traversa, G., Da Cas, R., Leone, R., Caputi, A.
(2006). Niflumic Acid and Mucocutaneous Reactions. Pediatrics
117: 253-254
[Full Text] -
Sturkenboom, M., Nicolosi, A., Mannino, S., Giaquinto, C., Cantarutti, L.
(2006). Niflumic Acid and Mucocutaneous Reactions: In Reply. Pediatrics
117: 254-255
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Sturkenboom, M., Nicolosi, A., Cantarutti, L., Mannino, S., Picelli, G., Scamarcia, A., Giaquinto, C., for the NSAIDs Paediatric Research Group,
(2005). Incidence of Mucocutaneous Reactions in Children Treated With Niflumic Acid, Other Nonsteroidal Antiinflammatory Drugs, or Nonopioid Analgesics. Pediatrics
116: e26-e33
[Abstract] [Full Text]
eLetters:
Read all eLetters
- Niflumic acid and cutaneous reactions: a controversial association.
- Grigoletto Francesco
- ADC Online, 6 Jul 2001 [Full text]
- Use of niflumic acid in children
- Maurizio Bonati, et al.
- ADC Online, 8 Nov 2001 [Full text]
- Niflumic acid and cutaneous reactions in children: a reply
- Francesca Menniti-Ippolito
- ADC Online, 19 Nov 2001 [Full text]
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