Article
Short report
Pancreatic dysfunction in severe obesity
A J Drake, L Greenhalgh, R Newbury-Ecob, E C Crowne, J P H Shield
The Royal
Hospital for Sick Children, St Michael's Hill, Bristol BS2 8BJ,
UK
Correspondence to: Dr Shield j.p.h.shield{at}bristol.ac.uk
Accepted 9 August 2000
AIMS
To investigate pancreatic
function in children attending an obesity clinic.
METHODSThirty six children (of
which 34 were white) with severe obesity of prepubertal onset (body
mass index more than +2 SDS) were reviewed clinically and
dysmorphologically, with assessment of pancreatic function.
RESULTSEight had dysmorphic
features and 13 had learning difficulties. Four of 17 prepubertal
children had hyperinsulinaemia and seven had hyperproinsulinaemia. All
19 pubertal children had hyperinsulinaemia, 14 had
hyperproinsulinaemia, and one had type II diabetes.
CONCLUSIONSMetabolic abnormalities
predictive of type II diabetes occur in severely obese white children.
Keywords: obesity; non-insulin dependent diabetes mellitus; syndromic obesity
© 2001 by Archives of Disease in Childhood
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This article has been cited by other articles:
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Drake, A J, Smith, A, Betts, P R, Crowne, E C, Shield, J P H
(2002). Type 2 diabetes in obese white children. Arch. Dis. Child.
86: 207-208
[Abstract] [Full Text] -
Day, C.
(2001). The rising tide of type 2 diabetes. British Journal of Diabetes & Vascular Disease
1: 37-43
[Abstract]
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