Nocturnal oximetry in infants with cystic fibrosis
M P Villaa, J Pagania, V Lucidib, S Palamidesa, R Ronchettia
a Clinica Pediatrica,
Università "La Sapienza", Viale Regina Elena, 324, I-00161 Rome,
Italy, b Bambino Gesù Hospital, Rome, Italy
Correspondence to: Prof. Villa mariapia.villa{at}uniroma1.it
Accepted 15 August
2000
AIM
To investigate whether children
with cystic fibrosis under 3 years of age have disordered breathing and
episodes of oxygen desaturation during sleep.
METHODSWe studied 19 infants (9 boys and 10 girls) with cystic fibrosis, mean age 13.1 months (range
3-36 months) and 20 age and sex matched healthy subjects. Patients and
controls underwent an overnight polysomnographic study and respiratory
function testing on the following morning.
RESULTSSeven patients with ongoing
respiratory tract inflammation had disordered breathing and episodes of
oxygen desaturation during sleep. Pulse oximetry showed a significantly
lower mean oxygen saturation (SaO2) and a
higher percentage of total sleep time spent with
SaO2 less than 93% in symptomatic children
than in controls.
CONCLUSIONResults suggest that
infants and young children with cystic fibrosis and mild airways
inflammation (rhinitis, cough, red throat) have episodes of oxygen
desaturation during sleep.
Keywords: cystic fibrosis; sleep; oxygen desaturation
© 2001 by Archives of Disease in Childhood
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Airway biology
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Immunology (including allergy)
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