Article
An association between sudden infant death syndrome (SIDS) and
Helicobacter pylori infection
J R Kerra, A Al-Khattafa, A J Barsonb, J P Burniea
a Infectious Diseases
Research Group, The University of Manchester, Clinical Sciences
Building, Manchester Royal Infirmary, Oxford Road, Manchester M13
9WL, UK, b Department of Paediatric Pathology, The
University of Manchester
Correspondence to: Dr Kerr jonathankerr{at}hotmail.com
Accepted 18 July 2000
BACKGROUND
Helicobacter
pylori has recently been detected in the stomach and trachea of
cases of sudden infant death syndrome (SIDS) and proposed as a cause of SIDS.
AIMSTo establish the incidence of
H pylori in the stomach, trachea, and lung
of cases of SIDS and controls.
METHODSStomach, trachea, and lung
tissues from 32 cases of SIDS and eight control cases were examined
retrospectively. Diagnosis of SIDS was based on established criteria.
Controls were defined by death within 1 year of age and an identifiable
cause of death. Tissues were examined histologically for the presence
of bacteria. Extracted DNA from these tissues was tested for
H pylori ureC and
cagA sequences by nested polymerase chain
reaction and amplicons detected by enzyme linked immunosorbent assay
(ELISA). The cut off for each ELISA for each of the tissue types was
taken as the mean optical density plus two times the standard deviation
of a range of negative controls.
RESULTSAges of SIDS cases ranged
from 2 to 28 weeks. Ages of controls ranged from 3 to 44 weeks. For the
ureC gene, 25 SIDS cases were positive in
one or more tissues compared with one of the controls. For the
cagA gene, 25 SIDS cases were positive in
one or more tissues compared with one of the controls.
CONCLUSIONSThere is a highly
significant association between H pylori
ureC and cagA
genes in the stomach, trachea, and lung of cases of SIDS when compared
with controls.
Keywords: Helicobacter pylori; sudden infant death syndrome
© 2000 by Archives of Disease in Childhood
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