Article
Outcome of invasive pneumococcal disease: a UK based study
F Shackleya, K Knoxb, J Bowen Morrisa, D Crookb, D Griffithsa, R Mayon-Whitec, R Georged, L Willockse, ER Moxonf, for the
Oxford Pneumococcal Surveillance Group
a Oxford Vaccine
Group, University of Oxford, UK, b Department of
Microbiology, John Radcliffe Hospital, Oxford OX3 9DU, UK, c Department of
Public Health, Oxford, UK, d Central
Public Health Laboratory, PHLS, Colindale, London, UK, e PHLS Communicable Disease Surveillance Centre
(Anglia and Oxford), UK, f University Department of Paediatrics, Oxford, UK
Correspondence to: Dr Crook email: dcrook{at}worf.molbiol.ox.ac.uk
Accepted 11 April 2000
METHODS
The records of 106 children
aged less than 5 years with invasive disease caused by
Streptococcus pneumoniae were reviewed.
RESULTSThe clinical manifestations
were meningitis (37%), upper respiratory tract infection (24%),
pneumonia (19%), and occult bacteraemia (18%). One child died and
seven had persisting neurological impairment. Five serotypes caused
83% of disease and 92% of the serotypes are included in the seven
valent conjugate vaccines which are undergoing trials.
CONCLUSIONSThese data suggest
that S pneumoniae infection is associated
with a low case fatality rate but substantial morbidity in the UK.
Keywords: Streptococcus pneumoniae; morbidity; mortality; outcome
© 2000 by Archives of Disease in Childhood
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