Arch Dis Child 2000;83:31-34 ( July )

Article

Recent advances

Recent advances in the genetics of severe childhood obesity I Sadaf Farooqi, Stephen O'Rahilly

University Departments of Medicine and Clinical Biochemistry, Box 157, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK

Correspondence to: Dr Farooqi email: ifarooqi{at}hgmp.mrc.ac.uk

Accepted 5 April 2000

Childhood obesity is becoming a global epidemic. Twin studies suggest a heritability of fat mass, and disorders of energy balance that arise from genetic defects have been identified. In the past three years, five single gene disorders resulting in early onset obesity have been characterised. The discovery of these genetic defects has biological and clinical implications which are greater than the rarity of the individual diseases might suggest.


Keywords: obesity; genetic defect

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© 2000 by Archives of Disease in Childhood
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