Recent advances
Recent advances in management of acute leukaemia
Judith M Chessells
Camelia
Botnar Laboratories, Institute of Child Health, 30 Guilford Street,
London WC1N 1EH, UK
Correspondence to: Prof. Chessells
Accepted 7 March 2000
There have been significant improvements in the outlook for
children with acute leukaemia but these advances are only available to
a minority of the world's children. There is still room for improvements in conventional chemotherapy and these need evaluation in
randomised trials. The role of bone marrow transplants in first remission is evolving as chemotherapy becomes more effective. New
treatments are needed for relapsed patients. Molecular diagnosis has
refined the assessment of prognosis but the extra value afforded by
measurement of minimal residual disease is not clear. International collaboration is needed to evaluate treatment for rare subtypes of leukaemia.
Keywords: acute leukemia; treatment; review
© 2000 by Archives of Disease in Childhood
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