Article
Sclerosing treatment of lymphangiomas with OK-432
C Luzzatto, P Midrio, Z Tchaprassian, M Guglielmi
Divisione di
Chirurgia Pediatrica, Via Giustiniani 3, 35128 Padova, Italy
Correspondence to: Dr Luzzatto
Accepted 16 November 1999
Over a period of seven years, 15 patients (aged from
birth to 15 years; median 22 months) with lymphangioma were treated
with OK-432; they received a mean of three injections each. Ten
received OK-432 as first line treatment; five were treated after
surgery (three had a residual lymphangioma after incomplete removal and two had a late recurrence). OK-432 proved to be effective for primitive
as well as for residual and recurrent lymphangioma. Seven cases were
macrocystic; complete regression was obtained in all. Five cases were
microcystic: two had more than 50% regression, and three less than
50%. Three cases were mixed, with both large and microscopic cysts:
one had more than 50% regression, and two less than 50%. These last
two cases underwent surgery after the sclerosing treatment. The results
obtained were excellent in 100% of macrocystic cases; a shrinkage in
size was obtained in all microcystic cases. OK-432 is therefore
proposed as a first line option for treatment of lymphangiomas.
Keywords: OK-432; lymphangioma
© 2000 by Archives of Disease in Childhood
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