Article
Fits, pyridoxine, and hyperprolinaemia type II
Valerie Walkera, Graham A Millsb, Sheila A Petersc, W Louis Mertond
a Department of
Chemical Pathology, Southampton General Hospital, Tremona Road,
Southampton SO16 6YD, UK, b School of Pharmacy and Biological Sciences,
University of Portsmouth, White Swan Road, Portsmouth PO1 2DT, UK, c Department of Paediatrics,
St Mary's Hospital, Milton Road, Portsmouth PO3 6AD, UK, d Department
of Neurophysiology, St Mary's Hospital
Correspondence to: Dr Walker
Accepted 22 November
1999
The rare inherited disorder hyperprolinaemia type II presents
with fits in childhood, usually precipitated by infection. A diagnosis
of hyperprolinaemia type II and vitamin B6 deficiency was
made in a well nourished child with fits. It is thought that pyridoxine
deficiency was implicated in her fits and was the result of
inactivation of the vitamin by the proline metabolite,
pyrroline-5-carboxylate.
Keywords: pyridoxine; fits; hyperprolinaemia type II; pyrroline-5-carboxylate
© 2000 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Mitsubuchi, H., Nakamura, K., Matsumoto, S., Endo, F.
(2008). Inborn Errors of Proline Metabolism. J. Nutr.
138: 2016S-2020S
[Abstract] [Full Text] -
VIVEKANANDAN, S
(2000). Fits, pyridoxine, and hyperprolinaemia type II. Arch. Dis. Child.
83: 87d-87
[Full Text] -
Farrant, R. D., Walker, V., Mills, G. A., Mellor, J. M., Langley, G. J.
(2001). Pyridoxal Phosphate De-activation by Pyrroline-5-carboxylic Acid. INCREASED RISK OF VITAMIN B6 DEFICIENCY AND SEIZURES IN HYPERPROLINEMIA TYPE II. J. Biol. Chem.
276: 15107-15116
[Abstract] [Full Text]
eLetters:
Read all eLetters
- Fits, pyridoxine and hyperprolinaemia type II
- S Vivekanandan
- ADC Online, 31 Mar 2000 [Full text]
- Full Text
- Full Text (PDF)
- Submit a response
- Read responses to this article
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
