Are glomerular filtration rate estimations necessary before high dose methotrexate?
H Rees, I M Hann, J M Chessells, D K H Webb
Department of
Haematology, Camelia Botnar Laboratories, Great Ormond Street Hospital
for Children, London WC1N 3JH, UK
Correspondence to: Dr Webb.
Accepted 4
June 1999
Glomerular filtration rates (GFR) were estimated in 168 children (227 estimates) before treatment for haematological
malignancies with high dose, intravenous methotrexate. Clinical
management was altered on the basis of GFR in only two cases, both of
whom had tumour lysis syndrome. Routine estimations of GFR do not
contribute to management.
Keywords: methotrexate; glomerular filtration rate; haematological malignancies
© 1999 by Archives of Disease in Childhood
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