Randomised trial of LHRH analogue treatment on final height in girls with onset of puberty aged 7.5-8.5 years
Alessandra Cassio, Emanuele Cacciari, Antonio Balsamo, Milva Bal, Davide Tassinari
Department of
Paediatrics, Bologna University, Via Massarenti 11, 40138 Bologna,
Italy
Correspondence to: Professor Cacciari.
Accepted 4 June 1999
OBJECTIVE
To study the
effectiveness of luteinising hormone releasing hormone (LHRH) analogues
in improving final height in girls affected by early puberty.
PATIENTSForty six
consecutive girls with onset of puberty aged 7.5-8.5 years randomly
divided into two groups: one treated with 3.75 mg triptorelin
intramuscularly every four weeks (group 1); and the other with no
treatment (group 2).
RESULTSMean (SD)
chronological age at onset of menarche was significantly higher in
group 1 than in group 2 (11.9 (1.0) v 10.8 (0.7) years). However, mean (SD) height at menarche (152.7 (7.2)
v 152.5 (5.7) cm) and mean (SD) growth
after menarche (4.9 (3.0) v 5.4 (2.2) cm)
were similar in both groups. The mean (SD) final height was similar in
the two groups (group 1, 158.1 (6.2) cm; group 2, 158.6 (6.0) cm) and
not significantly different from target height. Fourteen of 20 patients
in group 1 and 12 of 18 patients in group 2 showed final height equal
to or higher than target height. Final heights of girls with poor
initial height prognosis were significantly lower than those of girls
with good prognosis, but in patients with the same initial height
prognosis, both groups showed final heights similar and not
significantly different from their target heights.
CONCLUSIONSLHRH
analogue has no apparent effect on final height in subjects with onset
of puberty between 7.5 and 8.5 years.
Keywords: early puberty; luteinising hormone releasing hormone analogue; final height; randomised trial
© 1999 by Archives of Disease in Childhood
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