Effect of formoterol on clinical parameters and lung functions in patients with bronchial asthma: a randomised controlled trial
Akgül Akp
narl, Ayfer Tuncer, Yldz Saraçlar, Bülent E 
ekerel, Ömer Kalayc
Pediatric
Allergy and Asthma Division, Hacettepe University, School of Medicine,
Department of Pediatrics, Hacettepe 06100, Ankara, Turkey
Correspondence to: Dr Akpnarl. email: allergy{at}gen.hun.edu.tr
Accepted 30 September 1998
AIMS
To determine the
role of formoterol in the treatment of children with bronchial asthma
who are symptomatic despite regular use of inhaled corticosteroids.
METHODSA
randomised, double blind, parallel group, placebo controlled study to
investigate the effects of inhaled formoterol (12 µg twice a day) in
32 children with moderate to severe bronchial asthma. The study
consisted of two week run in periods and six week treatment periods,
during both of which the patients continued their regular
anti-inflammatory drugs. The efficacy parameters were symptom scores,
bronchodilator use, daily peak expiratory flow rates (PEFR),
methacholine hyper-reactivity, forced expiratory volume in one second
(FEV1), lung volumes, and airway conductance.
RESULTSFormoterol
treatment for six weeks decreased symptom scores, PEFR variability, and
the number of rescue salbutamol doses, and increased morning and
evening PEFR significantly. No adverse reactions were seen.
CONCLUSIONThese
findings suggest that inhaled formoterol is effective in controlling
chronic asthma symptoms in children who are symptomatic despite regular
use of inhaled corticosteroids.
Keywords: bronchial asthma; formoterol; asthma; randomised controlled trial
© 1999 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Ozdemir, C.
(2009). An immunological overview of allergen specific immunotherapy -- subcutaneous and sublingual routes. Ther Adv Respir Dis
3: 253-262
[Abstract]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
