Whole body bone mineral accretion in healthy children and adolescents
Christian Mølgaarda, Birthe Lykke Thomsenb, Kim Fleischer Michaelsena
a Research Department
of Human Nutrition and Centre for Advanced Food Studies, The Royal
Veterinary and Agricultural University, Rolighedsvej 30, DK-1958
Frederiksberg C, Denmark, b Department of Biostatistics, University of
Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark
Correspondence to: Dr Mølgaard.
Accepted 5 March
1999
Data on accretion in bone size and bone mineral content
(BMC) are needed to evaluate bone mineralisation during childhood. Whole body bone mineral content (BMC) and bone area (BA) were determined by dual energy x ray
absorptiometry (Hologic 1000/W) with a one year interval in healthy
girls (n = 192) and boys (n = 140) aged 6-19 years. Annual
accretion in BMC (
BMC (g/year)) and BA (BA
(cm2/year)) according to sex and pubertal stages were
calculated. BA and BMC were highly significantly associated with
pubertal stages in girls and boys. Centile curves for BA and BMC
according to sex and age were constructed using the LMS method. Peak
BA and BMC values were reached earlier in girls (12.3 and 12.5 years, respectively) than in boys (13.4 and 14.2 years, respectively). The BA peak was dissociated in time from the BMC peak, indicating that increase in bone size occurs before increase in bone mineral content. Assuming that 32.2% of BMC consist of calcium, the median (90th centile) annual bone calcium accretion in pubertal stage III was
220 mg/day (302) and 317 mg/day (386) for girls and boys, respectively. To obtain an average bone calcium accretion, a high calcium absorption is needed during puberty. This may have implications for dietary calcium requirements at this time.
Keywords: bone growth; bone mineral content; dual energy x ray absorptiometry
© 1999 by Archives of Disease in Childhood
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