Partial remission phase of diabetes in children younger than age 10 years
a The
Children's Hospital, Leicester Royal Infirmary, Leicester LE1 5WW, UK, b Department of Epidemiology and Public Health,
Leicester University, Leicester LE1 6PT, UK
Correspondence to: Dr Swift.
Accepted 18
December 1998
There is renewed interest in the phase of partial remission in
recently diagnosed diabetes because of the potential for
pharmacological and immune intervention to preserve 
cell function.
95 children younger than 10 years were investigated to assess the
influence of age, sex, diabetic ketoacidosis (DKA), admission at
diagnosis, and ethnicity on the frequency of remission and insulin
requirements during the first two years after diagnosis. Partial
remission was defined as a requirement of insulin < 0.5 U/kg body
weight/day. There was partial remission in 41 patients, with no
differences for children aged 2-4 years and those aged 5-9 years.
None of the five children aged < 2 years remitted. Forty five of 95 children were admitted to hospital at diagnosis, of whom 26 of 45 had
DKA (blood pH < 7.25). In this number of children we were unable to show a statistical difference in the rate of remission with respect to
DKA, admission to hospital at diagnosis, sex, or South Asian ethnic
background. There were no differences in insulin requirements between
the different groups by the end of two years and at that time seven of
the children required insulin < 0.5 U/kg/day. The results suggest
that even in preschool children there is potential for attempting to
preserve cell function.
© 1999 by Archives of Disease in Childhood
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