Growth in Sotos syndrome
a City
Hospital NHS Trust, Dudley Road, Birmingham B18 7QH, UK, b Birmingham Children's Hospital NHS
Trust, Steelhouse Lane, Birmingham B4 6NL, UK, c Institute of
Medical Genetics, University Hospital of Wales, Heath Park, Cardiff CF4
4XU, UK, d Clinical
Genetics Unit, Birmingham Women's Hospital, Edgbaston,
Birmingham B15 2TG, UK
Correspondence to: Dr Cole.
Accepted 15 December
1998
Although there are several reports on infant and
childhood growth in patients with Sotos syndrome, there is little
information on the final height achieved and puberty. Growth data on 40 patients (20 female and 20 male) aged 2-31 years were collected. These showed that patients with Sotos syndrome are excessively tall at birth,
during infancy, and during childhood. Disproportionately long limbs
constitute much of the increase in stature. However, the combination of
advanced bone age and early onset of menarche led to a mean (SD) final
height of 172.9 (5.7) cm in women. This is within the normal range for
the population. Most of the men also attained a final height (mean,
184.3 cm; SD, 6.0) within the normal range, although exceptions were
more likely in men than in women. Therefore, these results show that
most patients with Sotos syndrome do not require intervention to limit
their adult height.
© 1999 by Archives of Disease in Childhood
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