Randomised controlled trial of aminophylline for severe acute asthma
Intensive Care
Unit, Royal Children's Hospital, Melbourne, Victoria 3052, Australia
Correspondence to: Dr South. email: south{at}cryptic.rch.unimelb.edu.au
Accepted 11 May 1998
OBJECTIVES
To determine whether
children with severe acute asthma treated with large doses of inhaled
salbutamol, inhaled ipratropium, and intravenous steroids are conferred
any further benefits by the addition of aminophylline given intravenously.
STUDY DESIGNRandomised, double
blind, placebo controlled trial of 163 children admitted to hospital
with asthma who were unresponsive to nebulised salbutamol.
RESULTSThe placebo and treatment groups of
children were similar at baseline. The 48 children in the aminophylline
group had a greater improvement in spirometry at six hours and a higher
oxygen saturation in the first 30 hours. Five subjects in the placebo
group were intubated and ventilated after enrolment compared with none
in the aminophylline group.
CONCLUSIONSAminophylline continues to have a
place in the management of severe acute asthma in children unresponsive
to initial treatment.
© 1998 by Archives of Disease in Childhood
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