Production of antibodies to staphylococcal superantigens in atopic dermatitis
Department of
Immunology, Royal Children's Hospital, Parkville, Victoria 3052, Australia
Correspondence to: Dr Kemp. email: kempa{at}cryptic.rch.unimelb.edu.au
Accepted 12
June 1998
Staphylococcal superantigens (SAG) are implicated in the
inflammation of atopic dermatitis. As SAG mediated diseases may be modified by specific antibodies, the antibody response to SAG in atopic
dermatitis was investigated. Immunoglobulin (Ig) G to staphylococcal
enterotoxin A (SEA), staphylococcal enterotoxin B (SEB), and toxic
shock syndrome toxin 1 (TSST-1) were measured by sandwich enzyme linked
immunosorbent assay (ELISA) in 74 children with atopic dermatitis and
111 controls. Controls had detectable IgG to SEA, SEB, and TSST-1,
which increased with age. Atopic dermatitis subjects had an increased
response to SEB at 6 months to 2 years (76% v 42%) and 2 to 7 years (79% v 57%), and equivalent responses to SEA
and TSST-1, compared to controls. It is suggested that increased
responses to SEB relate to increased colonisation and hence exposure to
superantigen producing staphylococcus in atopic dermatitis, and that
inflammation of atopic dermatitis is not caused by an inability to make
antibody to SAG.
© 1998 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Lebon, A., Labout, J. A. M., Verbrugh, H. A., Jaddoe, V. W. V., Hofman, A., van Wamel, W. J. B., van Belkum, A., Moll, H. A.
(2009). Role of Staphylococcus aureus Nasal Colonization in Atopic Dermatitis in Infants: The Generation R Study. Arch Pediatr Adolesc Med
163: 745-749
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
