Colonic wall thickness, pancreatic enzyme dose and type of preparation in cystic fibrosis
Regional Paediatric Cystic Fibrosis Unit, St James's
University Hospital, Beckett Street, Leeds LS9 7TF, UK
Correspondence to: Dr Moya.
Accepted 27 February 1998
Increased colonic wall thickness has been reported in patients
exposed to large doses of high strength pancreatic enzyme preparations who did not develop fibrosing colonopathy. This has been interpreted as
evidence for a spectrum of subclinical disease. The relation between
sonographically measured colonic wall thickness and pancreatic enzyme
preparation and dose was studied in 86 children with cystic fibrosis
(CF). Colonic wall thickness of a control group was also measured. The
average thickness in all colonic regions was higher in the CF group
(overall average range 0.7-2.5 mm v 0.6-1.4 mm in the
control group). There was no significant relation between colonic wall
thickness and age, sex, total dose of lipase, or copolymer. Apart from
one patient with an early colonic stricture, none of those exposed to
high doses of lipase, or the methacrylic acid copolymer Eudragit L30
D55, showed evidence of subclinical damage to the colon. The
reproducibility of the sonographic measurements was poor.
© 1998 by Archives of Disease in Childhood
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