Efficacy of Zoladex LA (goserelin) in the treatment of girls with central precocious or early puberty
a Department of Child Health, Royal
Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, UK, b Department
of Diagnostic Imaging, Royal Hospital for Sick Children
Correspondence to: Dr Donaldson.
Accepted 12 May 1998
OBJECTIVE
To assess the efficacy of a longer
acting preparation of the gonadotrophin releasing hormone (GnRH)
analogue goserelin (Zoladex LA, 10.8 mg) in 12 girls with central
precocious or early puberty.
METHODSTwo girls started treatment de novo;
the remainder had been on suppressive treatment for a median duration
of 1.5 (range, 0.2-5.6) years. Assessment comprising auxology,
pubertal staging, and pelvic ultrasound examination was carried out at
weeks 0, 4, 8, 10, and 12 (first cycle) and weeks 8, 10, and 12 (second cycle) to evaluate the required injection frequency. Thereafter, assessment was performed on the day of injection. Zoladex LA was given
every 12 weeks unless pubertal progression occurred.
RESULTSSatisfactory control was achieved in eight
patients using this regimen, and three patients required more frequent
injections. One girl was removed from the study because of clinical
progression and extreme mood swings. No serious adverse effects
occurred. Mean height velocity during the study period was 4.5 cm/year
(range, 3.1-6.6) compared with 6.5 cm/year (range, 3.8-9.6) before
treatment in nine patients for whom data were available.
CONCLUSIONSZoladex LA was effective in
controlling precocious puberty in girls when given at intervals of
9-12 weeks and it is recommended that an initial assessment is made
eight weeks after beginning treatment.
© 1998 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
O'Sullivan, E, O'Sullivan, M, Mann, N
(2002). Precocious puberty: a parent's perspective. Arch. Dis. Child.
86: 320-321
[Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
