Management of acute diarrhoea with low osmolarity oral rehydration solutions and Lactobacillus strain GG
a Department of
Paediatrics, Jorvi Hospital, Turuntie 150, FIN 02740 Espoo, Finland, b Department of Paediatrics,
University of Turku, Turku, Finland, c Department of Paediatrics, Helsinki University
Hospital, Helsinki, Finland, d University
of Tampere, Medical School, Tampere, Finland
Correspondence to: Dr Rautanen.
Accepted 9
March 1998
Two hypotonic oral rehydration solutions with osmolarities of
224 mosmol/l (Na+ 60 mmol/l, glucose 84 mmol/l) and
204 mosmol/l (Na+ 60 mmol/l, glucose 64 mmol/l),
respectively, and oral treatment with
Lactobacillus GG were evaluated in a double
blind trial in children aged 6-36 months hospitalised for acute
diarrhoea. Early administration of
Lactobacillus GG at the start of oral
rehydration resulted in the shortest duration of diarrhoea, best weight
gain, and fastest correction of acidosis. A reduced osmolarity oral rehydration solution (224 mosmol/l) combined with early administration of Lactobacillus GG is an effective
treatment for acute diarrhoea in young children; further reduction of
osmolarity may not be beneficial.
© 1998 by Archives of Disease in Childhood
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