Melatonin treatment in an institutionalised child with psychomotor retardation and an irregular sleep-wake pattern
a Pediatrics
Department A, Rambam Medical Center, Haifa 31096, Israel, b Sleep
Laboratory, Gutwirth Building, Technion-IIT, Haifa, Israel
Correspondence to: Dr Pillar, MD.
Accepted 5 January
1998
An institutionalised 13 year old girl with psychomotor
retardation suffered from an irregular sleep-wake pattern. Multiple measurements of urinary sulphatoxymelatonin (aMT6) concentrations were abnormally low, without any significant day-night differences. Administration of exogenous melatonin (3 mg) at 18:00 resulted in
increased nocturnal urinary aMT6 concentrations and improvements in her
sleep-wake pattern. Melatonin may help disabled children suffering
from sleep disorders.
© 1998 by Archives of Disease in Childhood
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