Infant growth and aorta total lipid fatty acids
a Department of
Biochemistry, Royal Hospital for Sick Children, Yorkhill NHS Trust,
Glasgow G3 8SJ, Scotland, UK, b University Department of Child
Health, Royal Hospital for Sick Children, c Department of Pathology, Royal Hospital
for Sick Children
Correspondence to: Dr Farquharson.
Accepted 20 January
1998
Abnormal fetal and infant growth have increasingly been
correlated with adult onset cardiovascular disease. To date, there is
little known about the lipid fatty acid profiles in infant cardiovascular tissue. Therefore, we analysed total lipid fatty acids
from thoracic and abdominal aorta intima and media from 24 normally
grown sudden infant death syndrome cases. Aorta from small for
gestational age (n = 2), failure to thrive from birth (n = 3), and
premature (n = 1) infants were also examined. Dihomo-
-linolenic acid (C20:3n-6) and oleic acid (C18:1n-9) concentrations were significantly lower in the thoracic than in the abdominal aorta. Similar dietary related differences were found in the subgroup (n = 15) of infants fed on formula milks. Both abdominal and thoracic intimal arachidonic (C20:4n-6) to dihomo--linolenic acid ratios were
greater in the infants with retarded growth after birth than in their
normally grown counterparts. Growth restriction in infancy might
disrupt the normal accretion of vascular endothelial polyunsaturated fatty acids.
© 1998 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Rump, P., Mensink, R. P, Kester, A. D., Hornstra, G.
(2001). Essential fatty acid composition of plasma phospholipids and birth weight: a study in term neonates. Am. J. Clin. Nutr.
73: 797-806
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
