Prediction of lung function in the inadequately nourished
a Centre for Research
into Human Development, Department of Child Health, University of
Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK, b Department of Epidemiology and Public Health,
University of Dundee
Correspondence to: Dr Mukhopadhyay.
Accepted 11 February 1998
BACKGROUND
In animal
models, nutritional deficiency leads to profound qualitative changes in
the lung beyond an effect on organ size. Although lung growth is
non-isotropic, predictive values for spirometric lung function in
children are corrected for height alone. Prediction of lung function
should consider isotropic growth and nutritional status concurrently.
AIMTo establish
whether nutritional status influences lung function following the
exclusion of the effect of isotropic growth.
METHODSNutritional
status (weight, body mass index, mid-upper arm circumference, and
subscapular and triceps skinfold thicknesses) was assessed, and lung
function (forced vital capacity (FVC), forced expiratory volume in one
second (FEV1), and peak expiratory flow rate (PEFR)) was
measured in 391 healthy school age children with normal respiratory
history and examination in a rural setting in West Bengal, India.
RESULTSLung function
normalised for sitting height and stature correlated significantly with
indices of nutrition in both sexes. Adding weight as an independent
variable to sitting height, new reference prediction equations for
FEV1, FVC, and PEFR were calculated.
CONCLUSIONSNutritional
differences influence qualitative aspects of lung development in
childhood beyond simple isotropic lung growth. Prediction of lung
function must take account of these differences if change as a result
of disease is to be accurately measured. The
identification and correction of relevant dietary deficiencies might
help to improve lung function in children.
© 1998 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
VanderJagt, D. J., Trujillo, M. R., Jalo, I., Bode-Thomas, F., Glew, R. H., Agaba, P.
(2008). Pulmonary Function Correlates with Body Composition in Nigerian Children and Young Adults with Sickle Cell Disease. J Trop Pediatr
54: 87-93
[Abstract] [Full Text] -
CELEDON, J. C., PALMER, L. J., LITONJUA, A. A., WEISS, S. T., WANG, B., FANG, Z., XU, X.
(2001). Body Mass Index and Asthma in Adults in Families of Subjects with Asthma in Anqing, China. Am. J. Respir. Crit. Care Med.
164: 1835-1840
[Abstract] [Full Text] -
Abrams, S. A.
(2001). Chronic Pulmonary Insufficiency in Children and Its Effects on Growth and Development. J. Nutr.
131: 938S-941
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
