Arch Dis Child 1998;78:453-456 ( May )

Randomised controlled trial of sucrose by mouth for the relief of infant crying after immunisation

P J Lewindon,^a L Harkness,^a N Lewindon^b

^a Women's and Children's Hospital, Adelaide, South Australia, ^b Wakefield Street, Adelaide, South Australia

Correspondence to: Dr Peter Lewindon, Royal Children's Hospital, Brisbane, Herston, Queensland 4029, Australia.

Accepted 1 December 1997

OBJECTIVESTo evaluate the effect of sucrose solution given by mouth on infant crying times and measures of distress in the immunisation clinic.
DESIGNRandomised, double blind, placebo controlled trial of sucrose solution 75% wt/vol v sterile water as a control.
SETTINGThe immunisation clinic of the Women's and Children's Hospital, Adelaide.
PATIENTSA total of 107 healthy infants attending for 2, 4, or 6 month immunisations with polio by mouth (Sabin), intramuscular diphtheria, tetanus, and pertussis (DTP), and intramuscular Haemophilus influenzae type b were randomised to receive 2 ml 75% sucrose solution or sterile water by mouth before the two injections.
METHODSThe duration of infant crying was recorded during and immediately after two intramuscular immunisations and infant distress was assessed by a visual analogue scale (Oucher scores) independently by a nurse and a parent.
RESULTSThe administration of 2 ml 75% sucrose solution by mouth reduced the infant crying time and Oucher distress scores after immunisation with DTP/H influenzae type b.
CONCLUSIONSInfant immunisation by intramuscular injection is a distressing procedure for infants and parents. Sucrose solution at a high concentration reduces infant distress and is safe and clinically useful in this setting.

Keywords: infant analgesia; sucrose; immunisation

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© 1998 by Archives of Disease in Childhood
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