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Archives of Disease in Childhood 1998;78:349-353; doi:10.1136/adc.78.4.349
Copyright © 1998 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
Arch Dis Child 1998;78:349-353 ( April )

Management of tuberculosis in Wales: 1986-92

Verghese Mathew,a Mazin Alfaham,a Meirion R Evans,d Haydn Adams,b Roger Verrier Jones,a Ian Campbell,c Tony Jenkinse

a Llandough Hospital and Community NHS Trust, Penarth, South Glamorgan, Department of Child Health, b Department of Radiology, c Department of Respiratory Medicine, d Department of Public Health Medicine, South Glamorgan Health Authority, Cardiff, e Public Health Laboratory Service Mycobacterium Reference Laboratory, Cardiff Public Health Laboratory

Correspondence to: Dr M Alfaham, Department of Child Health, Llandough Hospital and Community NHS Trust, Penlan Road, Penarth, Vale of Glamorgan CF64 2XX.


Accepted 22 December 1997

OBJECTIVES---To describe the epidemiology of childhood tuberculosis in Wales and to assess the standard of management of patients with tuberculosis.
DESIGN---Retrospective study of data retrieved from case notes and review of radiographs of all identified patients.
SUBJECTS---Forty eight cases of tuberculosis and 10 of tuberculosis chemoprophylaxis in children under 15 years of age, in Wales, between January 1986 and December 1992.
MAIN OUTCOME MEASURES---Management of childhood tuberculosis in Wales compared with the published recommendations of the Joint Tuberculosis Committee of the British Thoracic Society.
RESULTS---Documentation was poor in most of the 48 cases of tuberculosis and only 31 (65%) were formally notified. One third of patients were asymptomatic and were detected by contact tracing; only eight (17%) were culture positive. Only 20% of patients from ethnic minorities had previously been immunised with BCG. Management and chemotherapy varied widely. Few patients were managed jointly by paediatricians and chest doctors. Only 10% completed treatment with a recommended chemotherapy regimen. In 37% of patients treatment was inadequate, and in the remainder either the choice of drugs or the duration of treatment was inappropriate. No patient died, nor had any relapsed by June 1995.
CONCLUSIONS---Very few cases of childhood tuberculosis were managed according to the recommendations of the British Thoracic Society.

Key messages

  • One third of patients with childhood tuberculosis were not notified

  • Most case of tuberculosis were in white children

  • Two thirds of patients had pulmonary disease; only two had tuberculous meningitis and none died

  • BCG immunisation status and tuberculin skin test results were poorly documented

  • Very few patients were jointly managed by paediatricians and chest doctors

  • Drug treatment was often inappropriate, either with respect to the choice of drugs or the duration of treatment




Keywords: patient management; drug regimens; treatment recommendations


© 1998 by Archives of Disease in Childhood

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This article has been cited by other articles:

  • Fathoala, B, Evans, M R, Campbell, I A, Sastry, J, Alfaham, M (2006). Active surveillance for tuberculosis in Wales: 1996-2003. Arch. Dis. Child. 91: 900-904 [Abstract] [Full Text]  
  • Srinivasan, R, Menon, L, Stevens, P, Campbell, I, Alfaham, M (2006). Ethnic differences in selective neonatal BCG immunisation: white British children miss out. Thorax 61: 247-249 [Abstract] [Full Text]  
  • CORRIGAN, D L, BLAND, R M, PATON, J Y (1999). Management of tuberculosis in Wales: 1986-92. Arch. Dis. Child. 80: 579a-579 [Full Text]  

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