Soluble thrombomodulin and antibodies to bovine glomerular endothelial cells in patients with Henoch-Schönlein purpura
a Kochi Medical School, Kochi, Japan:
Department of Paediatrics, b Second Department of Medicine, c Department of Paediatric Nephrology, Kidney Centre,
Tokyo Women's Medical College, Tokyo, Japan
Correspondence to: Dr Mikiya Fujieda, Department of Paediatrics, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi 783, Japan.
Accepted 25 September 1997
AIM
To evaluate the clinical significance of
soluble thrombomodulin and antiendothelial cell antibodies (AECA)
in children with Henoch-Schönlein purpura.
METHODSBinding of serum AECA to bovine
glomerular endothelial cells was evaluated by enzyme linked
immunosorbent assay, cytotoxicity against glomerular endothelial cells
by spectrophotometric assay, and soluble thrombomodulin concentrations
by sandwich enzyme immunoassay.
RESULTSIgA AECA were detected in seven of 15 patients with Henoch-Schönlein purpura and nephritis, but were not
detected in patients without nephritis or in controls. Patients with
Henoch-Schönlein nephritis had raised titres of IgA AECA and serum
thrombomodulin; severe proteinuria and renal histological changes were
associated with raised titres of IgA AECA and raised serum
thrombomodulin. No subjects had complement dependent cytotoxicity
against glomerular endothelial cells.
CONCLUSIONSHigh titres of IgA AECA and raised
serum thrombomodulin may be clinically useful markers of renal
involvement in patients with Henoch-Schönlein purpura.
© 1998 by Archives of Disease in Childhood
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Tizard, E J
(1999). Henoch-Schonlein purpura. Arch. Dis. Child.
80: 380-383
[Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
