Tuberous sclerosis complex and Wolff-Parkinson-White syndrome
a Bath Unit for
Research into Paediatrics, Children's Centre, Royal United Hospital,
Combe Park, Bath BA1 3NG, b Department of Cardiology, Royal United
Hospital, Bath, c Bristol Royal Hospital for
Sick Children, Bristol, d Wessex
Regional Cardiothoracic Unit, Southampton General Hospital, Southampton
Correspondence to: Dr Osborne.
Accepted 4 October 1997
This report highlights the association between tuberous
sclerosis and Wolff-Parkinson-White syndrome. Ten patients with
concurrent diagnoses of Wolff-Parkinson-White syndrome and tuberous
sclerosis were identified. Wolff-Parkinson-White syndrome presented
early in life, nine cases being diagnosed in the first year. Eight of the 10 cases were male. In eight cases, the syndrome was associated with supraventricular tachycardias, and in nine with cardiac
rhabdomyomata. One child died from cardiac failure secondary to
obstruction of the left ventricular outflow tract by a rhabdomyoma.
Five of nine survivors showed resolution of Wolff-Parkinson-White
syndrome on follow up. The accessory pathway was localised in nine
patients from surface electrocardiograms: six children had left sided
pathways and three had right sided pathways.
© 1998 by Archives of Disease in Childhood
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