Randomised controlled trial of tyrosine supplementation on neuropsychological performance in phenylketonuria
a University of Toronto and Hospital for Sick Children,
Toronto, Canada: Department of Psychology, b Department of Pediatrics and Division of
Clinical Genetics, c Clinical Biochemistry
Correspondence to: Dr Mary Lou Smith, Department of Psychology, Erindale College, University of Toronto, Mississauga, Ontario L5L 1C6, Canada. e-mail: smithml{at}psych.utoronto.ca
Accepted 4 September
1997
OBJECTIVE
To test the efficacy of tyrosine
supplementation, as an adjunct to dietary treatment, on
neuropsychological test performance in individuals with phenylketonuria.
DESIGNA randomised controlled trial of tyrosine
supplementation using a double blind crossover procedure with three
four week phases.
SETTINGThe Hospital for Sick Children, Toronto.
PARTICIPANTS21 individuals with
phenylketonuria (ages 6 to 28 years, mean 11.3).
INTERVENTIONParticipants were given 100 mg/kg
body weight/d of L-tyrosine or L-alanine (placebo).
RESULTSAt baseline, performance on several of the
neuropsychological test measures was correlated with tyrosine levels.
Dietary supplements of tyrosine increased plasma tyrosine
concentrations; however, no change in test performance was found across
the tyrosine and placebo phases of the study.
CONCLUSIONSTyrosine supplementation of this type
does not appear to alter neuropsychological performance in individuals
with phenylketonuria.
© 1998 by Archives of Disease in Childhood
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This article has been cited by other articles:
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National Institutes of Health Consensus Developmen,
(2001). National Institutes of Health Consensus Development Conference Statement: Phenylketonuria: Screening and Management, October 16-18, 2000. Pediatrics
108: 972-982
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Bross, R., Ball, R. O., Clarke, J. T. R., Pencharz, P. B.
(2000). Tyrosine requirements in children with classical PKU determined by indicator amino acid oxidation. Am. J. Physiol. Endocrinol. Metab.
278: E195-E201
[Abstract] [Full Text]
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